IL19 and Anxiety: Further efforts were conducted to explore whether IL-19 was involved in the pathogenesis of colon and anxiety; we measured the levels of IL-19 in colon of only DSS-treated and DSS/CUS models and found that the messenger RNA (mRNA) levels of IL-19 were increased in DSS/CUS treated mice, but not exclusively DSS treated mice (Figure 4A, Mann Whitney test, p=0.1807; Figure 4B, Unpaired t test with Welch’s correction, p=0.0086).