After we proved the effect of peripheric IL-19 in the colon in the activity of the ERK-CREB-BDNF pathway, another question was raised about the role of IL-19 in the hippocampus in the anxiety-related behaviors and potential signaling pathway; in our research, we observed that the mRNA levels of IL-19 in the hippocampus were not significantly changed in the DSS/CUS model (data not shown), indicating hippocampal IL-19 may not be extensively involved in the DSS/CUS induced anxiety behaviors. The gene discussed is CREB1; the disease is Anxiety.