Numerous studies have demonstrated the vital oncogenic role of AURKB (30), BIRC5 (31), KIF11 (32), PLK1 (33), PLK4 (34), RAD51 (35), TOP2A (36), TTK (37), and TUBB3 (38) in various cancers, including HCC. This evidence concerns the gene TUBB3 and hepatocellular carcinoma.