PSEN1 and Alzheimer disease: 5xFAD APP with Swedish, Florida, and London and PS1 with M146L, L286VAnd3xTg-AD PS1(M146V), ßAPP (Swedish) and tau (P301L)And3xTg-AD PS1(M146V), ßAPP (Swedish) and tau (P301L) with Itgal-/-