aPLs, including IgG and/or IgM aCL antibodies, IgG and/or IgM anti-β2-GPI antibodies, and Lupus Anticoagulant (LA) are established as laboratory criteria for diagnosis of the APS, characterized by arterial and venous thrombosis and recurrent abortions (17). Here, CD40LG is linked to autoimmune polyendocrinopathy.