In 2013 and 2014, the high-frequency keywords were “fecal microbiota”, “nf-kappa b”, “tregs”, “il-17 (interleukin-17)”, “autoreactive t”, “oxide”, etc., suggesting that a large number of studies focused on the function of immune cells to explore the involvement of GM in the process of RA. The gene discussed is IL17A; the disease is rheumatoid arthritis.