PSMB8 and early-onset autosomal dominant Alzheimer disease: Conversely, others have identified PSMB8 (i.e. β5i) loss-of-function mutations as disease-causing in autoinflammatory syndromes (95–99, 103–105) and PSMB8 knockout causing elevated inflammation in mouse models of myocarditis (112), Alzheimer’s disease (113) and pancreatitis (114).