The results showed that the expression levels of PYGB (Figure 10C), IFNGR2 (Figure 10F), TICAM1 (Figure 10I), STAT6 (Figure 10L) and VPS4B (Figure 10O) in CHOL tissues showed an overall upward trend compared with non-tumor hepatobiliary duct tissues. This evidence concerns the gene VPS4B and neoplasm.