In the TCGA-UCEC dataset, APOBEC3G, CUL4B, SCML2, TSPYL5, and ZBTB16 were significantly downregulated in tumor samples, whereas FOXP3, HJURP, HMGB3, and RAC3 were significantly upregulated in tumor samples (Figure S4A), which was generally consistent with the result observed in GSE17025 (Figure S4B). The gene discussed is ZBTB16; the disease is neoplasm.