According to the guideline of gynecologic pathology and WHO-defined histopathology, immature teratomas are characterized by immature neuroepithelium (rosettes and tubules), and neuroectodermal elements can be highlighted by neural markers, including NSE, GFAP, and SOX2, among them, SOX2 is more specific for immature neural tissue and diagnosis of immature teratoma (4). This evidence concerns the gene ENO2 and teratoma.