NIT1 and Nephropathy: To investigate the relationship between CGN risk locus gene expression and kidney tubule cell enrichment in R27 female AGN mice, we carried out linear regression analysis (Figure 5C), and found that log2 expression values for 7 of the 45 genes composing the Cgnz1 locus (Apoa2, Fcer1g, Ncstn, Ndufs2, Nit1, Pex19, Sdhc) were significantly correlated with GSVA scores for kidney distal tubule cells and thus could play a role in promoting resistance to kidney damage.