Many GOF mutations causing renal disease reside in ARs: G109S (AR1), P112Q (AR1), N125S (AR1), M132T (AR2), N143S (AR2), R175Q(AR3), whereas others are found in the C-terminus (e.g. Q899K, R895C, E897K) that is structurally proximate.20 Here, TCF20 is linked to kidney disorder.