Given that PANoptosis in SARS-CoV-2 infection may closely correlated with lung injury, multiple organ failure, and unfavorable prognosis in patients with severe COVID-19 (Karki et al., 2021; Lee et al., 2021), it is thus interesting to evaluate the role of BPOZ in PANotosis upon SARS-CoV-2 infection in the future. This evidence concerns the gene ABTB1 and COVID-19.