RUNX2 and cleidocranial dysplasia 1: Cleidocranial dysplasia (CCD) is an autosomal dominant heritable skeletal disease that affects cranial sutures, teeth, and clavicles, and the putative causative gene is Runt-related transcription factor 2 (RUNX2) (Xuan et al., 2010; Hordyjewska-Kowalczyk et al., 2019; Komori, 2020).