Studies have reported that CCD-associated RUNX2 mutations may reduce the proliferation and mineralization capacity of the SHED of the patient, along with their ability to induce odontoblast differentiation, which may be a cause of dental abnormalities in these patients (Xuan et al., 2010; Yan et al., 2015; Greene et al., 2018). This evidence concerns the gene RUNX2 and cleidocranial dysplasia 1.