Meanwhile, pro-inflammatory factor interferon gamma (IFN-γ) can significantly alter the ability of human NSC-derived EXOs (IFN-γ-hNSC-EXO) better than hNSC-EXO, and further induce therapeutic effects in ischemic stroke model rats through the miRNAs contained within, including miR-206, miR-133a-3p, and miR-3656 (Zhang et al., 2020). The gene discussed is IFNG; the disease is ischemic stroke.