EPHA2 and gastric cancer: For instance, ANXA2 directs the interaction of the protein YES1 and involves the EphA2-YES1-ANXA2 pathway (Mao et al., 2021), which promotes gastric cancer progression and metastasis, while ANXA6 (Wang et al., 2013) suppresses gastric cancer progression by inhibiting Ras/MAPK signalling.