Similarly, in lung cancer, the overexpression of ANXA8 activates the EGFR/AKT/mTOR signalling pathway to promote proliferation (Zhou et al., 2021a), while in thyroid cancer, increased ANXA1 promotes thyroid cancer proliferation by mediating IL-6/JAK2/STAT3 (Zhao et al., 2021). The gene discussed is ANXA8; the disease is lung cancer.