In contrast, the overexpression of the ANXA10 gene significantly inhibits HepG2 cell proliferation in vitro, and its downregulation inhibits papillary thyroid cancer proliferation; it acts directly on TSG101 by inactivating the MAPK/ERK signalling pathway (Wei and Zhu, 2021). Here, TSG101 is linked to thyroid gland papillary carcinoma.