Similarly, in lung cancer, the overexpression of ANXA8 activates the EGFR/AKT/mTOR signalling pathway to promote proliferation (Zhou et al., 2021a), while in thyroid cancer, increased ANXA1 promotes thyroid cancer proliferation by mediating IL-6/JAK2/STAT3 (Zhao et al., 2021). This evidence concerns the gene STAT3 and thyroid cancer.