These mice (from now on Sec22b−/−) fail to cross-prime CD8+ T cells to initiate responses against dead cells and tumor antigens if compared to their littermates (from now on Sec22b+/+) (Alloatti et al., 2017), but to our knowledge they were not studied in the context of infectious diseases that require cytotoxic responses to control the pathogen replication. This evidence concerns the gene SEC22B and infectious disease.