We showed that Sec22b-dependent XPt is important for mounting murine CD8+ T cell responses (in particular, specific for TsKb20) which, in turn, are essential for controlling infection with the T. cruzi Y strain, as evidenced by increased parasitemia, decreased body weight and decreased survival of XPt-impaired (Sec22b−/−) mice. This evidence concerns the gene SEC22B and parasitic infectious disease.