CD8A and neoplasm: These mice (from now on Sec22b−/−) fail to cross-prime CD8+ T cells to initiate responses against dead cells and tumor antigens if compared to their littermates (from now on Sec22b+/+) (Alloatti et al., 2017), but to our knowledge they were not studied in the context of infectious diseases that require cytotoxic responses to control the pathogen replication.