INPP5D and Alzheimer disease: Recent spatial transcriptomic studies focusing on inositol polyphosphate-5-phosphatase D (INPP5D) (Castranio et al., 2022), a risk gene for AD, found that knocking down INPP5D in PSAPP mice significantly altered the plaque-specific gene expression profile, exacerbated plaque deposition, and increased the number of microglia associated with plaque.