More recently, several staging or scoring systems for HCC prognosis, including the Barcelona Clinic Liver Cancer (BCLC) stage (8), Child–Turcotte–Pugh (CTP) class (9), tumor-node-metastasis (TNM) stage (10), and albumin-bilirubin (ALBI) grade (11) have been applied to assess the prognosis of HCC patients, while no one is most widely accepted with more accurate prediction ability. This evidence concerns the gene ALB and hepatocellular carcinoma.