Ferroptosis occurs after hemorrhagic strokes and is induced by lipid ROS via intracellular iron.109,112ALOX5 (aka 5-LOX and Arachidonate 5-Lipoxygenase), up-regulated in Deep ICH, is a major contributor to buildup of oxidized lipids.109,112,113 N-acetylcysteine, which inhibits ALOX5 oxidation of lipids, improved outcomes in experimental ICH.109,112 Intracellular iron can also be sequestered into the iron storage protein complex ferritin.109FTL, a part of the ferritin complex, was down-regulated in Lobar ICH. This evidence concerns the gene ALOX5 and hemorrhagic stroke.