Previous studies indicated that pore forming proteins (PFPs) such as BAX/BAK, mixed lineage kinase domain-like (MLKL) and gasdermins (GSDs) play a significant role in addressing tumor resistance via non-apoptotic cell death (Shi et al., 2015; Flores-Romero et al., 2020; Martens et al., 2021; Garciaz et al., 2022). Here, MLKL is linked to neoplasm.