CASP1 and Alzheimer disease: Acupuncture can decrease the expression of NLRP3 and NLRP1 inflammasome-related proteins and regulate the NLRP3/Caspase-1 pathway negatively (Ding et al., 2017; Jiang et al., 2018; He et al., 2020a; Li et al., 2021a; Zhang et al., 2021); (4) TLR4, distributed in microglia and astrocytes, is an important pattern recognition receptor involved in the neuroinflammatory response in AD.