MAPT and Alzheimer disease: There are currently several claims in the clinic to the related pathogenesis of Alzheimer’s disease, namely the cholinergic doctrine, the tau protein hypothesis, the neurovascular doctrine, the oxidative stress doctrine, the β- Amyloid theory, the brain-gut axis theory, etc., whether brain extracellular amyloid peptide exists β (Aβ) Deposition and intracellular tau protein (Tau) hyperphosphorylation while neurofibrillary tangles are the pathological diagnostic criteria of the disease, but the exact etiology of the AD is not well understood, and an effective cure for the AD is lacking to date.