GSK3B and Alzheimer disease: Wang et al. (2020c) studied the therapeutic effects of acupuncture “Baihui” and “Shenshu” at different frequencies (50, 30, and 2 Hz) on AD rats and the underlying mechanisms. The results showed that acupuncture downregulated GSK-3β levels in the hippocampus of AD Rats, upregulated GAP-43 levels, and 50 Hz acupuncture improved learning and memory function and repaired synaptic damage in AD rats better than 30 and 2 Hz (Lin et al., 2018).