This may be due to a potential anti-inflammatory effect that can reduce the ratio of TNF-α to IL-4 in T2DM patients, balance immunity with anti-inflammation, and help maintain glucose homeostasis, so as to regulate the transduction of insulin signaling, thereby regulating the conduction of insulin signals such as fasting blood glucose (FBG) level (59–61). Here, TNF is linked to type 2 diabetes mellitus.