Previous studies have shown that increased GCNT1, IFITM10, EXTL1, RILP, BBC3, RAB9A, MOB3B, SESN1, CDH4, MEIS1, RAB9A, NUDT7, and FMO2 are related to immune deficiency, autophagy inhibition, disease sensitivity and oxidative stress. The gene discussed is BBC3; the disease is Immunodeficiency.