For instance, HCC with low KLF4 expression, tumor stage III, and tumor differentiation grade I/II would have a total of 191 points (91 for KLF4 expression, 0 for tumor differentiation grade I/II, and 100 for tumor stage III), corresponding to a predicted 1-year OS of 42.0%. This evidence concerns the gene KLF4 and hepatocellular carcinoma.