TLR4 has been shown to be involved in immune responses to inflammatory signaling pathways that promote gastric carcinogenesis and to inhibit the immune response by mediating macrophage M2-type polarization, promoting tumor cell metastasis and being strongly associated with the outlook for those diagnosed with gastric cancer (He et al., 2018; Li et al., 2021). This evidence concerns the gene TLR4 and neoplasm.