Besides, tumor microenvironment (TME) was vital for the effect of immunotherapy, in which tumor cells themselves can upregulate the expression of PD-L1 and stimulate the expression of PD-L1 in TME cells, and thus suppresses antitumor immune response of cytotoxic T-cells (Alsaab et al., 2017). The gene discussed is CD274; the disease is neoplasm.