Consequently, 18 m6A-related mRNAs (PMM2, ERI1, NEK9, USP53, CNOT3, CDK5RAP2, ING5, HMGXB4, SH3D19, UBE2H, CLK1, SFPQ, UBP1, PDCD6IP, ZNF248, SCL25A53, CLCC1 and GPR125) were finally selected to construct a m6A-related prognostic risk score for CRC survival (Supplementary Figures S2A, S2B). Here, USP53 is linked to colorectal carcinoma.