METTL3 and colorectal carcinoma: METTL3 enhances translation of oncogene BRD4 through forming an mRNA loop in lung adenocarcinoma, and promotes expression of SRY (sex-determining region Y)-box 2 (SOX2) through IGF2BP2-directed suppression of RNA degradation in CRC (Choe et al., 2018; Li et al., 2019).