Likewise, another experimental study showed that METTL3 stabilizes HK2 and SLC2A1 (GLUT1) expression in CRC through an m6A-IGF2BP2/3- dependent mechanism, thereby pointing to the notion that m6A modification is a promising indicator of controlling human CRC aggressiveness (Shen et al., 2020). The gene discussed is METTL3; the disease is colorectal carcinoma.