In the future, studying the C9orf72 intermediate allele and tagging SNP genotype combinations in Finnish FTD cohort will be important to further replicate our findings and C9orf72 haplotypes should be analyzed more in detail to uncover the putative HRE-independent effect of this ALS/FTD locus. This evidence concerns the gene C9orf72 and amyotrophic lateral sclerosis.