The analysis of causal pathways (Figure 4A) shows evident pathways and significant changes caused by radiation including CREB signaling in neurons and synaptogenesis signaling pathway, cardiac hypertrophy signaling (enhanced), insulin secretion signaling pathway, G-protein coupled receptor signaling, hepatic fibrosis signaling pathway, and pulmonary fibrosis idiopathic signaling pathway. The gene discussed is INS; the disease is cardiac hypertrophy.