For example, overexpression of miR-129-5P in clear cell renal cell carcinoma (CCRCC) inhibits the function of sialophorin, which eliminates the promotion effect of SPN on cell proliferation and invasion, while simultaneously inducing the cell cycle arrest of tumor cells in G0/G1 phase (Gao et al., 2021). The gene discussed is SPN; the disease is nonpapillary renal cell carcinoma.