Through WES for the genomic DNA from the pheochromocytoma tissue of the proband 6, we identified a genetic variant in RET (ret proto-oncogene),RET:NM_020975:exon11:c.1901G>A:p.C634Y (the codon 634 of TGC to TAC), which has a dbSNP number of rs75996173 (Figure 6B). This evidence concerns the gene RET and hereditary pheochromocytoma-paraganglioma.