NF1 and von Hippel-Lindau disease: In addition to the neural crest-derived endocrine cellular tumor, other neoplasms including hemangioblastoma in the retina and central nervous system and renal cell carcinoma could be found in the same individual with other kinds of syndromes such as multiple endocrine neoplasia type 2 (MEN 2), Von Hippel-Lindau syndrome (VHL), neurofibromatosis type1 (NF1) and familial pheochromocytoma/paraganglioma syndromes (Antonio et al., 2020).