The proband 4 with a retroperitoneal paraganglioma has a splice donor variant of SDHB, c.423 + 1 G>T, and the proband 5 with a pheochromocytoma and renal cell carcinoma has a missense variant of SDHB, c.662A>G (p. D221G). Here, SDHB is linked to renal cell carcinoma.