By WES for the genomic DNA from the paraganglioma tissue of the proband 4, we identified a genetic variant in SDHB (succinate dehydrogenase complex iron sulfur subunit B), SDHB: NM_003000: exon4: c.423 + 1 G>T, which has not been recorded in the dbSNP database (Figure 4B). Here, SDHB is linked to paraganglioma.