We identified 13 survival-associated genes involved in differential FA metabolism in this study, namely IL4I1, RDH16, CEL, ENO2, UBE2L6, ECI1, GABARAPL1, ACSL1, MAOA, ACADL, and GPD1. In order to test the independent prognostic value of survival- and FA metabolism-related DEGs, we performed independent prognostic analysis by combining clinical factors (such as gender, age, grade, and pathological stage) with genes and found that high expression levels of ALDH1A1 and UBE2L6 were protective against breast cancer. This evidence concerns the gene GPD1 and breast cancer.