TP53 and malignant colon neoplasm: Interestingly, however, in contrast to the outcomes observed in the p53 wild-type cell lines, autophagy inhibition in p53 mutant HT29, SW620, and SW480 cell lines using CQ blocked the cell death induced by topotecan treatment, indicating that the autophagy was cytotoxic in function in p53 mutant colon cancer cells.