Bone gene expression and regulation are complex processes, and scientific reports about AGEs and bone genes in patients with CKD is scarce.(28, 29, 30, 31, 32) In our study, we observed that AGEs may upregulate p53 and downregulate DKK1 gene expression in patients who presented above‐median trabecular bone AGEs accumulation. The gene discussed is TP53; the disease is chronic kidney disease.