incorporated 15 candidate genes i.e. NLRC4, IRF3, ANO6, GSDMC, TP53, FGF21, IL36B, DHX9, FOXO3, IL36G, IL18, GJA1, MST1, GZMB and GBP1 for the development of a PRG model related to breast cancer (48). This evidence concerns the gene FOXO3 and breast cancer.