No attenuation of the results was identified (model C plus log C reactive protein: hazard ratio for cardiovascular disease 1.39 (95% confidence interval 1.21 to 1.60), P<0.001; ischaemic heart disease 1.49 (1.28 to 1.74), P<0.001; and myocardial infarction 1.60 (1.25 to 2.05), P<0.001). This evidence concerns the gene CRP and heart disorder.