The objectives of the present pilot study were to assess whether expression patterns of inflammatory proteins, IL-1α, IL-1RA, CXCL-1/2, and hBD-1, known to be involved in psoriasis, could be measured from the skin surface of adult psoriasis patients using the FibroTx TAP technology, whether the measurements correlated with the disease severity and further, to explore whether these skin surface proteins could be used to measure pharmacodynamic effects of psoriasis treatment. This evidence concerns the gene DEFB1 and psoriasis.