Data collected on the baseline and after 4 weeks of treatment were combined for Spearman rank correlation analysis positive association between skin surface proteins, PASI (r > 0.4), and the values of erythema, induration, and desquamation was observed over time for CXCL-1/2 and IL-1RA (r > 0.3) indicating higher levels of skin surface CXCL-1/2, IL-1RA for higher disease severity (Supplementary Table S6). This evidence concerns the gene CXCL1 and Erythema.