To determine whether differences in the molecular expression patterns of IL-1α, IL-1RA, CXCL-1/2, and hBD-1, between non-lesional and lesional skin sites of psoriasis patients associated with alterations in physical properties of skin layers, FibroTx TAP measurements of these four proteins were correlated with ultrasound measurements. The gene discussed is IL1R1; the disease is psoriasis.