Comparing the levels of skin surface IL-1α, IL-1RA, CXCL-1/2, and hBD-1 captured from psoriasis patients’ lesional and non-lesional skin revealed statistically higher levels of IL-1RA (p < 0.001), CXCL-1/2 (p < 0.01), and hBD-1 (p < 0.05) on lesional skin (Figures 1A–D; Supplementary Figures S1A–D). The gene discussed is DEFB1; the disease is psoriasis.