CRELD2 and multiple epiphyseal dysplasia: They revealed that Creld2 was the most highly upregulated gene in chondrocytes from a Matn3 mutant model of multiple epiphyseal dysplasia (MED), which is a clinically variable and genetically heterogeneous chondrodysplasia characterized by mild short stature, joint pain, and stiffness and early onset osteoarthritis (98).