Here, seven sub-pathways, including cell cycle control, actin regulation, TGF-β, MAPK, PI3K-AKT, NF-κB, and the JAK-STAT signaling, were consistently mapped as targets of DEmiRNAs in the enriched KEGG pathways, which highlights them as the major cascades affected in PAS pathophysiology. This evidence concerns the gene TGFB1 and gonorrhea.