That was to say, with ovarian cancer as the exposure factor and the insulin secret rate as the outcome variable, we still got the causal relationship of the above two parties (OR 3.092427e-13 (3.816945e-23, 2.505434e-03), p=0.013, Figure 4), which was confirmed in the inversive MR analysis (Figure 5). The gene discussed is INS; the disease is ovarian carcinoma.