* Decreased breast cancer cell proliferation and induced a G1 cell arrest, acting on the oncogene PIM-1.* Inhibited breast cancer xenograft tumor growth in nude mice (25).* Improved the recognition ability of tumor cells by cytotoxic T lymphocytes and natural Killer cells in breast patients, while reduced levels induced in trained individuals briefly after exercising can avoid perpetuation of activation of immune responses (39).* Regulates hematopoietic progenitor growth and erythroid differentiation (41). The gene discussed is PIM1; the disease is breast carcinoma.