In accordance, the miR-150 expression in osteosarcoma tissues was significantly decreased compared with adjacent noncancerous tissues while the expression levels of a direct target of miR-150, insulin-like growth factor 2 mRNA-binding protein 2 (IGF2BP2) were markedly increased in osteosarcoma tissues (29) and oral cancer (30). This evidence concerns the gene IGF2BP2 and lip and oral cavity carcinoma.