The purpose of this study is to demonstrate the specificity of PTC detection by targeted microbubbles decorated with Gal-3 targeting polypeptide (C12, ANTPCGPYTHDCPVKR) in thyroid cancer models using CEUS imaging, which is quantitatively analyzed with advanced ultrasound quantification software (VueBox®; Bracco, Suisse SA, Geneva, Switzerland). Here, LGALS3 is linked to thyroid gland carcinoma.