PTEN and Down syndrome: Anxiety-RRB associations have also been reported in other diagnosed groups including Down syndrome (Uljarević and Evans, 2017), Fragile X syndrome (Lozano et al., 2022), 22q11.2 (Uljarević et al., 2019), and in individuals with PTEN mutations independent of ASD (Uljarević et al., 2022), although were not found in individuals with Williams syndrome (WS) even though the WS sample had elevated anxiety (Rodgers et al., 2012a).