PTEN and Down syndrome: Likewise, while RRBs are also found in a range of other genetic and clinical conditions; Prader-Willi syndrome, Williams syndrome, Fragile X syndrome, Angelman’s syndrome, Cri de Chat syndrome, Down syndrome, Lowe syndrome, Smith-Magenis, PTEN mutations, 22q11.2 deletion syndrome, obsessive compulsive disorder (OCD), Tic disorders, eating disorders, psychotic disorders, Attention deficit hyperactivity disorder (ADHD), RRBs often form defining diagnostic symptoms of these conditions or there is often a high incidence of overlapping diagnosis with ASD.