This review focuses on various cardiac Z-disk proteins (alpha-actinin, filamin C, titin muscle LIM protein, telethonin, myopalladin, nebulette, nexilin), all known to bind actin and to be associated with cardiomyopathies, and how genetic variants in these proteins are associated with different cardiomyopathies. This evidence concerns the gene CSRP3 and cardiomyopathy.