Homozygous mice with the (p.Gly650del) variant exhibited a progressive DCM phenotype characterized by disorganization of the transverse-axial tubular system and a reduction in T-tubule formation, underpinning the importance of the functional NEXN gene in cardiac function and tubular system organization (Liu et al., 2020). The gene discussed is NEXN; the disease is familial dilated cardiomyopathy.