Based on several previous studies, patients with mutations in STIM1 and ORAI1 exhibit ectodermal dysplasia with amelogenesis imperfecta, which further confirms the significance of SOCE in enamel mineralization (Feske et al., 2010; Lacruz and Feske, 2015; Silva-Rojas et al., 2020). The gene discussed is STIM1; the disease is amelogenesis imperfecta.