SLC6A3 and nervous system disorder: Several studies have suggested that Tat causes neurological disorders by interacting with monoamine transporters (DAT, serotonin, norepinephrine) as well as with N-methyl-D-Aspartate (NMDA) receptors in the central nervous system impairing their functional activity (Aksenova et al., 2006; Kumar et al., 2011; Purohit et al., 2011; Adeniran et al., 2021; Ayoub et al., 2023).