The area under curve (AUC) in predicting migraine, EM, CM in all subjects for GDF-15 was 0.801 (sensitivity 64.62%; specificity 89.66%), 0.780 (sensitivity 65.32%, specificity 86.29%), 0.880 (sensitivity 75.00%, specificity 92.00%), respectively. Here, GDF15 is linked to migraine disorder.