HAND2 and gastric cancer: wang et al. used LASSO analysis to identify four Pyroptosis-Related-lncRNAs (HAND2-AS1, LINC01354, RP11-276H19.1, and PGM5-AS1), and demonstrated that these four lncRNAs could well predict the prognosis of gastric cancer patients, and found that the pyroptosis risk score of gastric cancer was associated with clinicopathological features and TME alterations [17].