HFD can also contribute to activating genes involved in this phenomenon, such as CD11b, MHC-II, CX3CR1, NLRP3, and IL-1β in the hippocampus and amygdala, favoring the inflammatory environment that contributes to the neurodegeneration observed in obesity (Butler et al. 2020). The gene discussed is IL1B; the disease is obesity due to melanocortin 4 receptor deficiency.